Key result
Disruption of the mitral apparatus in dogs increased the equilibrium volume and slowed left ventricular relaxation without changing left ventricular diastolic stiffness or contractility.
Why the study?
Does disruption of the mitral apparatus alter left ventricular diastolic and systolic properties in a dog model?
Population
14 dogs (in situ left ventricle model)
Comparison
Disruption of the mitral apparatus vs Before disruption of the mitral apparatus
Design
Preclinical
Authors
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Requires human validation before informing valve surgery; leaves open translation of canine LV effects to clinical practice.
Does disruption of the mitral apparatus alter left ventricular diastolic and systolic properties in a dog model?
Disruption of the mitral apparatus increases equilibrium volume and slows left ventricular relaxation without changing stiffness or contractility, supporting the clinical practice of preserving the mitral apparatus during valve replacement.
Shintani et al. (1993) studied Left ventricular function (n=14). Disruption of the mitral apparatus vs. Before disruption (baseline) was evaluated on Left ventricular diastolic and systolic properties (V0d, V0s, V0sw, tau infinity). Disruption of the mitral apparatus in dogs increased the equilibrium volume and slowed left ventricular relaxation without changing left ventricular diastolic stiffness or contractility.
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