Key result
Treatment with ACE inhibitors was associated with significantly lower plasma beta-thromboglobulin levels compared with untreated hypertensives, whereas other antihypertensive classes were not.
Why the study?
Do different classes of antihypertensive drugs reduce in vivo platelet activation in patients with essential hypertension?
Population
101 patients, including 24 with untreated essential hypertension, 21 normotensive controls, and 56 treated…
Comparison
Antihypertensive therapy. vs Untreated essential hypertension and…
Design
Cross-sectional
Authors
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ACE inhibitors may lower platelet activation in hypertension; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=101)
Do different classes of antihypertensive drugs reduce in vivo platelet activation in patients with essential hypertension?
ACE inhibitors, unlike other common antihypertensive classes, are associated with significantly lower in vivo platelet activation in patients with essential hypertension, suggesting a potential additional mechanism for cardiovascular protection.
Islim et al. (1992) conducted a cross-sectional in Essential hypertension (n=101). Antihypertensive drugs (ACE inhibitors, beta-blockers, calcium antagonists, diuretics) vs. Untreated essential hypertension and normotensive controls was evaluated on Plasma beta-thromboglobulin levels. Treatment with ACE inhibitors was associated with significantly lower plasma beta-thromboglobulin levels compared with untreated hypertensives, whereas other antihypertensive classes were not.
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