Key result
Inhaled wood smoke evoked an immediate increase in vagal pulmonary C-fiber activity (+7.4 impulses/s) in rats, which was attenuated by the hydroxyl radical scavenger DMTU.
Population
58 anesthetized, open-chest, and artificially ventilated rats (68 pulmonary C fibers studied)
Comparison
6 ml of inhaled wood smoke delivered into the… vs Pretreatment with vehicle, removal of smoke…
Design
Preclinical
Follow-up
Seconds (immediate and delayed phases up to 8 seconds)
Authors
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No clinical implications from this rat model; leaves open whether hydroxyl radicals mediate C-fiber responses to smoke in humans.
Inhaled wood smoke stimulates vagal pulmonary C fibers in rats via its gas phase, mediated by hydroxyl radicals and cyclooxygenase products.
Lai et al. (1998) studied this question. inhaled wood smoke was evaluated on impulses from vagal pulmonary C fibers. Inhaled wood smoke evoked an immediate increase in vagal pulmonary C-fiber activity (+7.4 impulses/s) in rats, which was attenuated by the hydroxyl radical scavenger DMTU.
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