Key result
Neutralizing antibodies against the Fermon and dominant 2014 Missouri EV-D68 isolates were universally detected in serum samples collected during 2012-2013, indicating widespread circulation before the 2014 outbreak.
Cross-Sectional (n=436)
No
Widespread circulation of enterovirus D68 occurred before the 2014 outbreak, as neutralizing antibodies against the dominant 2014 isolate were universally detected in samples from 2012-2013.
Answers are grounded in this paper and cite their sources.
Indicates endemic EV-D68 circulation before 2014; leaves open whether viral changes drove outbreak severity.
We evaluated enterovirus D68 seroprevalence in Kansas City, Missouri, USA, from samples obtained during 2012-2013. Neutralizing antibodies against Fermon and the dominant 2014 Missouri isolate were universally detected. Titers increased with age. Widespread circulation of enterovirus D68 occurred before the 2014 outbreak. Research is needed to determine a surrogate of protection.
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Harrison et al. (2019) conducted a cross-sectional in Healthy persons (n=436). Enterovirus D68 exposure was evaluated on Seroprevalence of neutralizing antibodies against EV-D68 isolates Fermon and 14-18949. Neutralizing antibodies against the Fermon and dominant 2014 Missouri EV-D68 isolates were universally detected in serum samples collected during 2012-2013, indicating widespread circulation before the 2014 outbreak.
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