Key result
Unilateral clipping of the renal artery reduced renin concentration in both clipped and untouched kidneys, while angiotensinase concentration remained equal to controls.
Why the study?
Does unilateral clipping of the renal artery alter kidney renin and angiotensinase concentrations in rats?
Population
30 rats, including normal controls, rats with renal hypertension produced by unilateral clipping of the…
Comparison
Unilateral clipping of the renal artery vs Normal unclipped rats
Design
Preclinical
Authors
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Should not alter clinical practice; hypothesis-generating for renin regulation in experimental renovascular hypertension.
Does unilateral clipping of the renal artery alter kidney renin and angiotensinase concentrations in rats?
Unilateral renal artery clipping in rats reduces kidney renin concentration, particularly in the untouched kidney, without altering angiotensinase concentration in those that develop hypertension.
Blaquier et al. (1961) studied Renal hypertension (n=30). Unilateral clipping of the renal artery vs. Normal (unclipped) rats was evaluated on Kidney renin and angiotensinase concentrations. Unilateral clipping of the renal artery reduced renin concentration in both clipped and untouched kidneys, while angiotensinase concentration remained equal to controls.
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