Key result
Quinidine Lipettes yielded more even serum concentrations and seemed to cause less troublesome side-effects than other marketed quinidine preparations.
Why the study?
Does a sustained release preparation of quinidine provide more even serum concentrations and fewer side-effects compared to other marketed quinidine preparations?
Does a sustained release preparation of quinidine provide more even serum concentrations and fewer side-effects compared to other marketed quinidine preparations?
A sustained release preparation of quinidine provides more stable serum concentrations and fewer side effects compared to standard preparations.
May support sustained-release quinidine evaluation; hypothesis-generating and should not yet change practice.
A new sustained release preparation (Lipettes) of quinidine has been evaluated with regard to dissolution, absorption, serum concentration and side-effects. The serum levels of quinidine after single oral doses and after long-term treatment have been compared with the serum levels after administration of some other quinidine preparations on the Swedish market. The side-effects of the sustained release preparations have also been studied. Results indicated that this new sustained release quinidine preparation yields more even serum concentrations of quinidine and seemed to cause less troublesome side-effects than the marketed preparations.
No takes yet. Share an insight, caveat, or question.
Eriksson et al. (1979) studied this question. Quinidine Lipettes vs. Other marketed quinidine preparations was evaluated on Serum concentration and side-effects. Quinidine Lipettes yielded more even serum concentrations and seemed to cause less troublesome side-effects than other marketed quinidine preparations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: