Key result
Phenotyping of macrophage and endothelial cell differentiation antigens detected myocardial inflammation in 80% of cardiac transplant biopsies, compared to 56% with conventional histopathology.
Why the study?
Does macrophage phenotyping using immunoperoxidase staining improve the detection of myocardial inflammation compared to conventional histopathology in cardiac transplant biopsies?
Observational (n=24)
Does macrophage phenotyping using immunoperoxidase staining improve the detection of myocardial inflammation compared to conventional histopathology in cardiac transplant biopsies?
Absolute Event Rate: 80% vs 56%
Phenotyping of macrophage and endothelial cell differentiation antigens offers a more sensitive approach than conventional histopathology for diagnosing myocardial inflammation in cardiac allografts.
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May increase sensitivity for detecting myocardial inflammation in cardiac allografts; hypothesis-generating pending prospective outcome studies.
Mues et al. (1991) conducted an observational in Orthotopic heart transplantation (n=24). Phenotyping of macrophage and endothelial cell differentiation antigens vs. Conventional histopathology was evaluated on Detection of myocardial inflammation. Phenotyping of macrophage and endothelial cell differentiation antigens detected myocardial inflammation in 80% of cardiac transplant biopsies, compared to 56% with conventional histopathology.
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