Key result
Elevated blood pressure under stress (≥140/90 mm Hg) in non-hypertensive patients was associated with significantly higher rates of >50% coronary artery stenosis and lower FMD (P < .05).
Why the study?
Does elevated blood pressure under stress correlate with vascular endothelial dysfunction and coronary artery stenosis in non-hypertensive patients suspected of CAD?
Observational (n=1,141)
Does elevated blood pressure under stress correlate with vascular endothelial dysfunction and coronary artery stenosis in non-hypertensive patients suspected of CAD?
p-value: p=< .05
Elevated blood pressure under stress during coronary angiography in non-hypertensive patients is associated with vascular endothelial dysfunction and significant coronary artery stenosis.
Supports hypothesis of stress BP elevation as endothelial dysfunction marker in non-hypertensives; leaves open prognostic value and need for prospective validation.
OBJECTIVES: The aim of the present study is to explore the correlation between vascular endothelial function and coronary artery stenosis in non-hypertensive patients with elevated blood pressure under stress. METHODS: This study included 1141 patients suspected of having coronary artery disease (CAD) without hypertension. Coronary arteriography and ultrasonic detection were used to measure the flow-mediated dilatation (FMD) function in the brachial artery. Patients were divided into 2 groups according to coronary angiography: experiment group, patients with blood pressure ≥ 140/90 mm Hg; control group, patients with blood pressure <140/90 mm Hg. The correlation between vascular endothelial function and coronary artery stenosis was observed. RESULTS: The majority of the patients in the control group were found to have either normal coronary arteries or stenosis <50%. Patients in the experiment group (those with invasive blood pressure [IBP] >140/90) were more likely to have some degree of coronary artery stenosis. Specifically, there were significantly more patients with >50% stenosis in the experiment when compared with the control group (P < .05). The FMD in the experiment group was significantly lower than that in the control group (P < .05). CONCLUSION: The non-hypertensive patients with elevated blood pressure under stress had coronary artery stenosis, which was associated with vascular endothelial dysfunction.
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Yang et al. (2014) conducted an observational in Suspected coronary artery disease without hypertension (n=1,141). Elevated blood pressure under stress (≥ 140/90 mm Hg) vs. Blood pressure <140/90 mm Hg was evaluated on Coronary artery stenosis >50% and flow-mediated dilatation (FMD) (p=< .05). Elevated blood pressure under stress (≥140/90 mm Hg) in non-hypertensive patients was associated with significantly higher rates of >50% coronary artery stenosis and lower FMD (P < .05).
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