Key result
Systemic high-dose corticosteroid treatment resulted in complete recovery and resolved hemodynamic instability in a patient with tetanus toxoid vaccine-associated eosinophilic myocarditis.
Case Report (n=1)
This case highlights the value of endomyocardial biopsy in diagnosing vaccine-associated eosinophilic myocarditis and demonstrates the efficacy of high-dose corticosteroids.
Raises suspicion for eosinophilic myocarditis post-tetanus vaccination; leaves open confirmation of causality and incidence.
Vaccine-associated myocarditis is an extremely rare, yet potentially lethal disease, which requires early diagnosis and prompt treatment. However, its pathogenesis remains elusive. We report the first case of biopsy-proven eosinophilic myocarditis related to tetanus toxoid immunization, with unique histopathologic findings, characterized by perivascular eosinophilic infiltrates with myocyte necrosis and abundant interstitial lymphocytic infiltrates with myocyte necrosis, separately. A systemic high-dose corticosteroid treatment had a dramatic beneficial effect on hemodynamic instability and resulted in complete recovery. This case highlights the value of endomyocardial biopsy in establishing a definite diagnosis and understanding the pathogenesis of vaccine-associated myocarditis.
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Yamamoto et al. (2018) conducted a case report in Eosinophilic myocarditis (n=1). Systemic high-dose corticosteroid treatment was evaluated on Hemodynamic instability and recovery. Systemic high-dose corticosteroid treatment resulted in complete recovery and resolved hemodynamic instability in a patient with tetanus toxoid vaccine-associated eosinophilic myocarditis.
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