Key result
Percutaneous adjustment of a novel deformable mitral annuloplasty ring increased leaflet coaptation length from 4.2 mm to 8.5 mm (P<0.001) in a sheep model at 6 months.
Why the study?
Does a novel deformable mitral annuloplasty ring allow percutaneous increase of mitral leaflet coaptation length in a healthy sheep model?
Does a novel deformable mitral annuloplasty ring allow percutaneous increase of mitral leaflet coaptation length in a healthy sheep model?
Absolute Event Rate: 8.5% vs 4.2%
p-value: p=<0.001
A novel deformable annuloplasty ring safely enabled significant and stable percutaneous improvement of mitral leaflet coaptation length in a sheep model.
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Preclinical feasibility of adjustable mitral ring supports further development; leaves open clinical efficacy pending human trials.
Tozzi et al. (2017) studied Mitral valve repair (preclinical model) (n=10). Deformable mitral annuloplasty ring with percutaneous adjustment vs. Baseline (pre-adjustment) was evaluated on Leaflet coaptation length (CL) (p=<0.001). Percutaneous adjustment of a novel deformable mitral annuloplasty ring increased leaflet coaptation length from 4.2 mm to 8.5 mm (P<0.001) in a sheep model at 6 months.
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