Key result
A commercial heart extract (Recosen) increased coronary flow but decreased force of beat in isolated perfused mammalian hearts, and potentiated the pressor effects of adrenaline in the spinal cat.
The commercial heart extract Recosen exhibits multiple pharmacological effects in preclinical models, including increased coronary flow and decreased myocardial contractility.
These animal data should not inform clinical use; leaves open further mechanistic and safety studies of heart extracts.
An investigation was made of the pharmacological properties of a commercial heart extract (Recosen), said to be of value in the treatment of angina pectoris. This extract increased coronary flow but decreased force of beat in isolated perfused mammalian hearts. It potentiated the pressor effects of adrenaline in the spinal cat whilst not affecting those of noradrenaline, and it antagonised the actions of adrenaline and noradrenaline upon intestinal muscle. A mild anticholinesterase activity was demonstrated on striped muscle. The significance of these findings is discussed.
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C.M. CONWAY (1959) studied this question. Commercial heart extract (Recosen) was evaluated on Pharmacological properties (coronary flow, force of beat, pressor effects). A commercial heart extract (Recosen) increased coronary flow but decreased force of beat in isolated perfused mammalian hearts, and potentiated the pressor effects of adrenaline in the spinal cat.
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