Key result
Tissue-derived bioprostheses remain limited by calcification and lack of durability, though novel crosslinking approaches and plasticizing molecules offer potential pathways for improvement.
Design
Review
Authors
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Durability concerns persist with tissue valves in practice; leaves open targeted development of crosslinking and anti-calcification strategies.
Highlights the need for novel crosslinking approaches and anti-calcification treatments to improve the durability of tissue-derived bioprosthetic heart valves.
Marcel E. Nimni (2001) conducted a review in Heart valve prostheses. Tissue-derived bioprostheses and glutaraldehyde fixation was evaluated. Tissue-derived bioprostheses remain limited by calcification and lack of durability, though novel crosslinking approaches and plasticizing molecules offer potential pathways for improvement.
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