Key result
Anti-PrP IgGs were found in 21 of 37,894 hospital patients without any enrichment of specific pathologies, suggesting that anti-PrP autoimmunity is innocuous.
Why the study?
Prion immunotherapy holds potential, but antibodies against certain PrP epitopes can be neurotoxic.
Population
48,718 samples from 37,894 hospital patients along with synthetic libraries and healthy human B-cell repertoires
Design
In vitro phage display, repertoire mining, and patient cohort serological survey
Authors
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May advance prion immunotherapy targeting flexible tail epitopes; leaves open clinical translation given Level 5 evidence.
Observational (n=37,894)
The presence of innocuous, neuroprotective anti-prion antibodies in human immunological repertoires suggests they may help clear nascent prions and contribute to the low incidence of spontaneous prion diseases.
Senatore et al. (2020) reported an observational. Anti-PrP IgGs was evaluated on Enrichment of specific pathologies. Anti-PrP IgGs were found in 21 of 37,894 hospital patients without any enrichment of specific pathologies, suggesting that anti-PrP autoimmunity is innocuous.
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