Key result
In patients undergoing TAVI, severe coronary artery disease (SYNTAX score >22) was associated with higher one-year mortality (OR 1.71; 95% CI 1.24-2.36).
Why the study?
The impact of coronary artery disease severity and percutaneous coronary intervention on outcomes after transcatheter aortic valve implantation remains a matter of debate.
Does the severity of coronary artery disease and its percutaneous revascularization impact mortality in patients undergoing TAVI?
Population
8,334 patients from 13 studies undergoing TAVI
Comparison
CAD presence, CAD severity (SS >22), and PCI revascularisation extent (rSS <8)
Design
Meta-analysis of multivariable-adjusted observational results
Follow-up
Up to 1 year
Authors
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May inform TAVI risk stratification by CAD severity; hypothesis-generating for revascularization trials.
Meta-Analysis (n=8,334)
Does the severity of coronary artery disease and its percutaneous revascularization impact mortality in patients undergoing TAVI?
Odds Ratio: 1.71 (95% CI 1.24–2.36)
High coronary artery disease complexity (SYNTAX score >22) increases 1-year mortality after TAVI, but achieving complete or near-complete revascularization (residual SYNTAX score <8) significantly reduces this risk.
D’Ascenzo et al. (2018) conducted a meta-analysis in Patients undergoing TAVI (n=8,334). Coronary artery disease severity (SYNTAX score >22) vs. Lower SYNTAX score was evaluated on Impact of CAD severity (assessed with the SYNTAX score) on one-year mortality (OR 1.71, 95% CI 1.24-2.36). In patients undergoing TAVI, severe coronary artery disease (SYNTAX score >22) was associated with higher one-year mortality (OR 1.71; 95% CI 1.24-2.36).
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