Key result
Two halogen-substituted isoflavenes reduced poliovirus type 2 viral yield by approximately 90% in vitro, likely by interfering with early translation of input RNA.
Two halogen-substituted isoflavenes inhibit poliovirus type 2 replication in vitro, likely by interfering with the early stage of translation of input RNA.
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No immediate clinical implications for poliovirus; leaves open preclinical optimization and in vivo testing of these isoflavenes.
Conti et al. (1990) studied poliovirus type 2 infection. halogen-substituted flavanoids (dichloroflavan, halogenated isoflavans, and isoflavenes) was evaluated on viral yield. Two halogen-substituted isoflavenes reduced poliovirus type 2 viral yield by approximately 90% in vitro, likely by interfering with early translation of input RNA.
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