Key result
Dahl hypertension-sensitive rats showed similar baroreflex sensitivity to normotensive rats using sigmoidal models, but linear regression revealed reduced sensitivity during pressure increases.
The method of statistical analysis (sigmoidal vs linear regression) significantly influences the determination of baroreceptor sensitivity in hypertensive and normotensive rat models.
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Analysis method influences baroreflex sensitivity assessment in hypertensive rat models; leaves open optimal approach for translational research.
Murphy et al. (1995) studied Hypertension. Dahl hypertension-sensitive (SS/Jr) strain vs. Normotensive (SR/Jr) strain was evaluated on Baroreflex sensitivity. Dahl hypertension-sensitive rats showed similar baroreflex sensitivity to normotensive rats using sigmoidal models, but linear regression revealed reduced sensitivity during pressure increases.
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