Key result
High mean platelet volume was associated with a 1.669-fold increased risk of carotid plaques compared to the lowest quintile in normotensive, euglycemic, and normolipidemic men.
Why the study?
Is mean platelet volume associated with carotid atherosclerosis in normotensive, euglycemic, and normolipidemic adults?
Cross-Sectional (n=654)
Is mean platelet volume associated with carotid atherosclerosis in normotensive, euglycemic, and normolipidemic adults?
Mean platelet volume is independently associated with carotid atherosclerosis in healthy males, suggesting its potential as an easily measured marker of subclinical atherosclerosis.
Supports MPV evaluation as subclinical atherosclerosis marker in healthy men; does not yet warrant clinical adoption.
We investigated whether mean platelet volume (MPV) is independently associated with the carotid intima-media thickness (cIMT) in normotensive, euglycemic, and normolipidemic middle-aged and elderly adults. A total of 256 males and 398 females were enrolled from the Changfeng Study. Compared to male patients with MPV in the first quintile, male patients with MPV in the fifth quintile had greater cIMTs and higher prevalence of carotid plaque. After adjusting for conventional cardiovascular disease risk factors, male participants with MPV in the fifth quintile had a 1.669-fold increased risk of carotid plaques relative to those in the lowest quintiles. In female patients, the cIMTs and prevalence of carotid plaque were not significantly different among the groups. These results suggest that MPV is independently associated with carotid atherosclerosis in normotensive, euglycemic, and normolipidemic males. The MPV could be an easily measured marker of atherosclerosis for males.
No takes yet. Share an insight, caveat, or question.
Ma et al. (2014) conducted a cross-sectional in Carotid atherosclerosis (n=654). High mean platelet volume (fifth quintile) vs. Low mean platelet volume (first quintile) was evaluated on Risk of carotid plaques (1.669-fold increased risk). High mean platelet volume was associated with a 1.669-fold increased risk of carotid plaques compared to the lowest quintile in normotensive, euglycemic, and normolipidemic men.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: