Key result
Prostaglandin E1 at concentrations of 100, 10, and 5 ng/ml inhibited platelet decrease in human heparinized blood circulating in a heart-lung machine in vitro.
Why the study?
Does Prostaglandin E1 prevent platelet decrease in human heparinized blood circulating in a heart-lung machine in vitro?
Does Prostaglandin E1 prevent platelet decrease in human heparinized blood circulating in a heart-lung machine in vitro?
PGE1 inhibits platelet decrease during in vitro circulation in a heart-lung machine, suggesting platelet adhesion and aggregation are involved in this process.
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PGE1 may preserve platelets in extracorporeal circuits; leaves open clinical translation to cardiopulmonary bypass.
Stibbe et al. (2009) studied Open heart surgery with the use of the heart-lung machine. Prostaglandin E1 (PGE1) was evaluated on Platelet decrease. Prostaglandin E1 at concentrations of 100, 10, and 5 ng/ml inhibited platelet decrease in human heparinized blood circulating in a heart-lung machine in vitro.
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