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August 30, 2010Scandinavian Cardiovascular JournalOpen Access

Activation of Notch signaling in cardiomyocytes during post-infarction remodeling

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Key result

Heart failure was associated with significant upregulation of Notch3 and Notch4 mRNA levels and their intracellular domains in cardiomyocytes (p < 0.05), indicating activation during remodeling.

Authors

EØErik ØieWSWiggo J. SandbergMAMohammad Shakil Ahmed

Discussion

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Overview

Hypothesis-generating for Notch modulation in HF remodeling; prospective studies needed before therapeutic exploration.

Study Design

Type

Observational

PICO

P
Population
Rats with heart failure after induction of myocardial infarction and humans with heart failure.
E
Exposure / Comparator
Heart failure vs Non-failing myocardium
O
Primary Outcome
Myocardial gene expression and localization of Notch receptors and ligands, p=< 0.05

Main Result

p-value: p=< 0.05

Cite This Study

Øie et al. (2010) conducted an observational in Heart failure. Heart failure vs. Non-failing myocardium was evaluated on Myocardial gene expression and localization of Notch receptors and ligands (p=< 0.05). Heart failure was associated with significant upregulation of Notch3 and Notch4 mRNA levels and their intracellular domains in cardiomyocytes (p < 0.05), indicating activation during remodeling.

synapsesocial.com/papers/6a9474f35cc4cfd2f72de027https://doi.org/10.3109/14017431.2010.511256
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications.1990 · 2,881 citations
  2. 2Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes2002 · 20,368 citations
  3. 3Notch Signaling1995 · 1,309 citations
  4. 4Activation of Notch-Mediated Protective Signaling in the Myocardium2008 · 205 citations