Key result
Expression of CD61p (cutoff 58.70) and CD62E/61 (cutoff 22.25) demonstrated 70% and 60% sensitivity, and 85% and 95% specificity, respectively, for the diagnosis of thrombotic MI.
Why the study?
Can cellular microparticles expressing CD61 and CD62E/61 be used for the early diagnosis of thrombotic myocardial infarction?
Observational
Can cellular microparticles expressing CD61 and CD62E/61 be used for the early diagnosis of thrombotic myocardial infarction?
Answers are grounded in this paper and cite their sources.
Cellular microparticles expressing CD61 and CD62E/61 show potential as biomarkers for the early diagnosis of thrombotic myocardial infarction.
Cellular microparticles are plasma membrane vesicles of 0.05). A cutoff value for the expression of CD61p as a marker of thrombotic MI was suggested to be (58.70) revealed (70%) sensitivity and (85%) specificity and as regards CD 62E/61, taking (22.25) as a cut-off point revealed (60%) sensitivity and (95%) specificity using ROC curve statistical method. In conclusions, the antithrombotic properties of low dose antiplatelet or anticoagulant therapy are not strong enough to suppress shedding of the microparticles. A cut off value for expression of CD61 and coexpression CD 62E/61 in MI patients can contribute to the clinical applications as using MP assay in early diagnosis of thrombotic propensity, monitoring of anticoagulant therapy, and detection the risk of ischemic heart diseases in high-risk patients.
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Khalil et al. (2019) conducted an observational in Cardio-vascular Ischemic Infarction. CD61p and CD62E/61 expression was evaluated on Diagnosis of thrombotic MI. Expression of CD61p (cutoff 58.70) and CD62E/61 (cutoff 22.25) demonstrated 70% and 60% sensitivity, and 85% and 95% specificity, respectively, for the diagnosis of thrombotic MI.
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