Key result
In hypertensive rats, 0.1% caffeine consumption reduced creatinine clearance at 10 weeks (3.6 vs 5.7 L/kg/day; p<0.02) and increased proteinuria at 20 weeks (1,202 vs 603 mg/kg/day; p<0.01).
Why the study?
Does long-term caffeine consumption worsen renal function in spontaneously hypertensive heart failure prone rats?
Population
Lean, male, 9-month-old spontaneously hypertensive heart failure (SHHF/Mcc-fa(cp)) rats
Comparison
Drinking water containing 0.1% caffeine for 20… vs Normal drinking water for 20 weeks
Design
Preclinical, randomized
Follow-up
20 weeks
Authors
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Caffeine may accelerate renal decline in hypertensive models; hypothesis-generating and should not change human practice without clinical trials.
RCT
randomized
Does long-term caffeine consumption worsen renal function in spontaneously hypertensive heart failure prone rats?
Absolute Event Rate: 3.6% vs 5.7%
p-value: p=<0.02
Prolonged caffeine consumption accelerates the decline in renal function and increases proteinuria in a rat model of high-renin hypertension.
Tofovic et al. (1999) conducted an RCT in high-renin hypertension. Caffeine vs. normal drinking water was evaluated on creatinine clearance at 10 weeks (p=<0.02). In hypertensive rats, 0.1% caffeine consumption reduced creatinine clearance at 10 weeks (3.6 vs 5.7 L/kg/day; p<0.02) and increased proteinuria at 20 weeks (1,202 vs 603 mg/kg/day; p<0.01).
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