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May 11, 2016Experimental Biology and MedicineOpen Access

Compared with the PTH1-34 group, atorvastatin significantly decreased cellular diameter by 12.07 µm, 3H-leucine incorporation by 1622 cpm/well, single-cell protein content by 84.34 pg, ANP by 7.13 ng/L, and BNP by 20.04 µg/L (P < 0.05).

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Why the study?

Does atorvastatin prevent cardiomyocyte hypertrophy induced by PTH1-34 in rat cardiomyocytes?

Population

Neonatal rat cardiomyocytes

Comparison

Atorvastatin (10(-5) mol/L) vs Normal controls, PTH1-34 (10 mol/L) alone, and…

Design

Preclinical, Randomly divided into seven groups

Authors

XLXiaogang LiuCZChunbo ZouCYChengyuan Yu

Discussion

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Overview

Atorvastatin attenuates PTH1-34-induced hypertrophy in rat cardiomyocytes; hypothesis-generating and should not yet change practice.

Structured PICO

Does atorvastatin prevent cardiomyocyte hypertrophy induced by PTH1-34 in rat cardiomyocytes?

P
Population
Neonatal rat cardiomyocytes
I
Intervention
Atorvastatin (10(-5) mol/L)
C
Comparator
Normal controls, PTH1-34 (10(-7) mol/L) alone, and other mechanistic groups (FTI-276, MVA)
O
Outcome
Cardiomyocyte hypertrophic responses (cell diameter, protein synthesis, single-cell protein content) and hypertrophic markers (ANP, BNP)surrogate

Atorvastatin prevents parathyroid hormone 1-34-induced cardiomyocyte hypertrophy in vitro, likely by inhibiting the Ras-ERK signaling pathway.

Cite This Study

Liu et al. (2016) studied this question.

synapsesocial.com/papers/6a953dfafa49e109e125e17ehttps://doi.org/10.1177/1535370216649259
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Atorvastatin on Expression of Peroxisome Proliferator-activated Receptor Beta/delta in Angiotensin II-induced Hypertrophic Myocardial Cells In Vitro2015 · 5 citations
  2. 2Atorvastatin Attenuates Myocardial Hypertrophy in Spontaneously Hypertensive Rats via the C/EBPβ/PGC-1α/UCP3 Pathway2018 · 17 citations
  3. 3Rat Parathyroid Hormone 1 − 34 Signals through the MEK/ERK Pathway to Induce Cardiac Hypertrophy2008 · 24 citations
  4. 4Prevention of Cardiac Hypertrophy by Atorvastatin in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy2005 · 160 citations
  5. 5Atorvastatin Slows the Progression of Cardiac Remodeling in Mice with Pressure Overload and Inhibits Epidermal Growth Factor Receptor Activation2008 · 31 citations