Key result
In vitro macrophage properties and responses to JM virus did not differ significantly between susceptible S- and resistant K-strain chickens, suggesting they do not account for genetic resistance.
Population
Macrophages from susceptible S- and resistant K-strain White Leghorn chickens
Comparison
Inoculation with JM virus (Marek's disease virus) vs Comparison between S- and K-strain macrophages
Design
Preclinical
Authors
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Macrophage function does not explain genetic resistance to Marek's disease; leaves open alternative cellular or molecular mechanisms for study.
In vitro macrophage properties do not account for the genetic resistance or susceptibility to Marek's disease in White Leghorn chickens.
Haffer et al. (1979) studied Marek's disease. Macrophages from resistant K-strain chickens vs. Macrophages from susceptible S-strain chickens was evaluated on Basic macrophage properties and response to JM virus. In vitro macrophage properties and responses to JM virus did not differ significantly between susceptible S- and resistant K-strain chickens, suggesting they do not account for genetic resistance.
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