Key result
In vivo selective suppression of macrophage functions by antimacrophage serum or trypan blue inoculations resulted in significantly elevated viral titers and increased tumorigenesis.
Population
Macrophages from S- and K-strain Leghorn chickens (susceptible and resistant to Marek's disease, respectively)
Comparison
In vivo selective suppression of macrophage… vs Infected, non-suppressed or non-infected control…
Design
Preclinical
Authors
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Supports macrophage surveillance against Marek's disease virus; leaves open genetic resistance mechanisms and human translation.
Macrophages play a surveillance role in Marek's disease infection, but genetic susceptibility or resistance is not controlled at the macrophage level.
Haffer et al. (1979) studied Marek's disease. Selective suppression of macrophage functions by antimacrophage serum or trypan blue inoculations vs. Infected, non-suppressed or non-infected control groups was evaluated on Viral titers and tumorigenesis. In vivo selective suppression of macrophage functions by antimacrophage serum or trypan blue inoculations resulted in significantly elevated viral titers and increased tumorigenesis.
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