Key result
Macrophage depletion in MDV-spleen cells resulted in a 4- to 18-fold higher virus titer and a 2-fold increase in isotope uptake compared to untreated cells.
Effect estimate: 4- to 18-fold higher titer; 2-fold higher isotope uptake
Macrophages restrict Marek's disease virus replication and lymphoma cell proliferation in chickens.
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Macrophage restriction of MDV in chickens extends avian immunology models; leaves open relevance to mammalian herpesvirus lymphomas.
Lucy F. Lee (1979) studied Marek's disease (MD) tumors in chickens. Macrophage depletion vs. Untreated cells (macrophages present) was evaluated on Virus titer and isotope uptake (4- to 18-fold higher titer; 2-fold higher isotope uptake). Macrophage depletion in MDV-spleen cells resulted in a 4- to 18-fold higher virus titer and a 2-fold increase in isotope uptake compared to untreated cells.
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