Key result
Naturally occurring nucleopeptidic replication primers (VPg-pUpU) of poliovirus and coxsackie virus were successfully chemically synthesized via block-coupling.
Demonstrates the successful chemical synthesis of picornaviral protein primers of RNA replication.
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Provides synthetic access to picornaviral primers for mechanistic studies; leaves open therapeutic applications.
Naturally occurring nucleopeptidic replication primers (VPg-pUpU) of poliovirus and coxsackie virus were chemically synthesized. The synthesis was accomplished via block-coupling of two minimally protected fragments of the target structures: a short RNA-nucleopeptide and a longer peptide segment containing diverse side-chain functionalities. The synthetic VPg-pUpU of coxsackie virus was characterized by NMR spectroscopy.
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Kriek et al. (2006) studied this question. Chemical synthesis of VPg-pUpU was evaluated. Naturally occurring nucleopeptidic replication primers (VPg-pUpU) of poliovirus and coxsackie virus were successfully chemically synthesized via block-coupling.
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