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June 1, 1987HypertensionOpen Access

Studies of isolated resistance vessels from offspring of essential hypertensive patients.

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Key result

Offspring of hypertensive patients demonstrated a significantly greater shift in resistance vessel sensitivity to norepinephrine in the presence of cocaine compared to matched controls.

Why the study?

Are functional and morphological changes present in the resistance vasculature of young normotensive offspring of essential hypertensive patients before hypertension is established?

Population

43 young normotensive subjects, comprising 21 with a family history of essential hypertension and 22…

Comparison

Assessment of isolated subcutaneous resistance… vs Vessels from 22 age-, sex-, and weight-matched…

Design

Case-control

Authors

CAChristian AalkjærVascular / Pulmonary VascularAHAnthony M. HeagertyPreventive CardiologyIBIan BaileyNational Oceanography Centre

Discussion

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Implication

May indicate preclinical vascular sensitivity changes in hypertension offspring; leaves open predictive value and need for prospective confirmation.

Study Design

Type

Case-Control (n=43)

Structured PICO

Are functional and morphological changes present in the resistance vasculature of young normotensive offspring of essential hypertensive patients before hypertension is established?

P
Population
43 young normotensive subjects, including 21 with a family history of hypertension and 22 matched controls.
E
Exposure
Assessment of isolated subcutaneous resistance vessels (morphology, reactivity, and sensitivity to vasoconstrictor agonists including norepinephrine, angiotensin II, serotonin, and vasopressin, with and without cocaine).
C
Comparator
Vessels from 22 age-, sex-, and weight-matched normotensive controls without a family history of hypertension.
O
Outcome
Morphological changes, reactivity, and sensitivity to vasoconstrictor agonists in isolated subcutaneous resistance vessels.surrogate

A defect in neuroeffector activity, manifested by altered norepinephrine sensitivity in the presence of cocaine, precedes the development of essential hypertension in offspring of hypertensive patients.

Cite This Study

Aalkjær et al. (1987) conducted a case-control in Essential hypertension (n=43). Family history of essential hypertension vs. Controls matched for age, sex, and weight was evaluated on Morphological changes and reactivity to vasoconstrictor agonists in isolated subcutaneous resistance vessels. Offspring of hypertensive patients demonstrated a significantly greater shift in resistance vessel sensitivity to norepinephrine in the presence of cocaine compared to matched controls.

synapsesocial.com/papers/6a95b08535af924ef23fcb54https://doi.org/10.1161/01.hyp.9.6_pt_2.iii155

Topics

Hypertension management
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Also Consider

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  4. 4AN INCREASED CALCIUM SENSITIVITY OF MESENTERIC RESISTANCE VESSELS IN YOUNG AND ADULT SPONTANEOUSLY HYPERTENSIVE RATS1980 · 192 citations
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