Key result
In pediatric heart transplant recipients, LV and RV early-diastolic filling normalized in 6 to 9 months (P<0.001), but RV systolic function remained impaired at 1 year (z score -1.2±1.1).
Why the study?
Does biventricular function recover to normal during the first year after heart transplant in rejection-free pediatric patients?
Population
44 pediatric heart transplant recipients who remained rejection-free during the first year post-transplant.
Comparison
Heart transplantation vs Age-based normative values from 380 healthy…
Design
Cohort
Follow-up
1 year
Authors
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RV systolic impairment at 1 year may warrant extended surveillance in pediatric transplant recipients; leaves open prognostic impact and intervention needs.
Cohort (n=44)
Does biventricular function recover to normal during the first year after heart transplant in rejection-free pediatric patients?
p-value: p=<0.001
In pediatric heart transplant recipients, most aspects of biventricular function normalize within 6 to 9 months, but right ventricular systolic function remains impaired at 1 year post-transplant.
Lunze et al. (2012) conducted a cohort in Heart transplant (n=44). Heart transplantation vs. Healthy children (normative values) was evaluated on Recovery of left and right ventricular function (z scores of systolic and diastolic velocities) (p=<0.001). In pediatric heart transplant recipients, LV and RV early-diastolic filling normalized in 6 to 9 months (P<0.001), but RV systolic function remained impaired at 1 year (z score -1.2±1.1).
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