Key result
Crystal structures and biochemical studies reveal that CAR-mediated clustering of JAML recruits PI3K to a JAML intracellular sequence motif, indicating their role as cell signaling receptors.
Authors
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No immediate clinical implications; leaves open cardiovascular roles for JAML-CAR signaling pending in vivo validation.
Key points are not available for this paper at this time.
Verdino et al. (2010) studied this question. Crystal structures and biochemical studies reveal that CAR-mediated clustering of JAML recruits PI3K to a JAML intracellular sequence motif, indicating their role as cell signaling receptors.
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