Key result
PD123319 (ATR type-2 blocker) significantly increased the speed of AngII-induced rat urinary bladder contraction compared to AngII alone or Losartan plus AngII.
Why the study?
The study aimed to apply a specific analysis on recordings obtained from urinary bladder preparations influenced by Angiotensin II and Angiotensin II receptor blockers.
Does the blockade of specific Angiotensin II receptors alter the speed of AngII-induced contractions in rat urinary bladder preparations?
Does the blockade of specific Angiotensin II receptors alter the speed of AngII-induced contractions in rat urinary bladder preparations?
Angiotensin II receptor subtypes mediate a reciprocal dynamic response to AngII in rat urinary bladder contractions.
AT1/AT2 receptors reciprocally shape AngII-driven bladder contractions in vitro; leaves open roles in human detrusor dysfunction.
OBJECTIVE: An application of a specific analysis on recordings obtained from urinary bladder (UB) preparations influenced with Angiotensin II (AngII) and AngII receptor (ATR) blockers was performed. METHODS: UB preparations were divided as follows: group 1 stimulated with AngII only; group 2:PD123319 (ATR type-2 blocker)+AngII; group 3:Losartan (ATR type-1 blocker)+AngII. The averaged time and force parameters of the contractions were processed by a spline interpolation and graphic images of the different patterns of the contractile activity were obtained. RESULTS: The speed of AngII-induced UB contraction, when PD123319 was administered, was significantly higher than those, registered by the application of AngII alone and Losartan + AngII. The presence of Losartan markedly delayed the speed of the overall AngII-induced contraction. CONCLUSION: The study indicates the contribution of both ATR subtypes for the development of AngII-induced UB contraction. Our results showed that probably ATR mediate a reciprocal dynamic response to AngII in the bladder.
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Hadzhibozheva et al. (2019) studied Urinary bladder contractions. PD123319 (ATR type-2 blocker) or Losartan (ATR type-1 blocker) + AngII vs. AngII alone was evaluated on Speed and force parameters of AngII-induced UB contraction. PD123319 (ATR type-2 blocker) significantly increased the speed of AngII-induced rat urinary bladder contraction compared to AngII alone or Losartan plus AngII.
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