Key result
Mild hypertension in rabbits did not lead to significant changes in atrial wall stress or either basal or stimulated release of atrial natriuretic factor compared to normotensive controls.
Population
12 rabbits
Comparison
Volume expansion by 30% of blood volume using… vs Sham-operated normotensive control rabbits…
Design
Preclinical
Follow-up
8 weeks
Authors
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Should not guide hypertension therapies targeting ANF; leaves open effects in severe models or other species.
In a rabbit model, mild hypertension does not alter atrial wall stress or the basal and stimulated release of atrial natriuretic factor in response to volume expansion and pacing.
King et al. (1992) studied Mild hypertension (n=12). Mild hypertension (renal wrapping) vs. Sham-operated controls was evaluated on Atrial wall stress and plasma atrial natriuretic factor (ANF) release. Mild hypertension in rabbits did not lead to significant changes in atrial wall stress or either basal or stimulated release of atrial natriuretic factor compared to normotensive controls.
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