Key result
Tachycardia at high blood volume significantly increased plasma immunoreactive atrial natriuretic factor and systolic right atrial wall stress in anesthetized rabbits.
Why the study?
Do tachycardia and altered blood volume affect atrial dynamics and atrial natriuretic factor release in anesthetized rabbits?
Population
Anesthetized rabbits
Comparison
Tachycardia and a slow 20% reduction and… vs Low blood volume and absence of tachycardia
Design
Preclinical
Authors
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Supports systolic atrial stress as ANF driver in rabbit tachycardia-hypervolemia; leaves open human translation.
Do tachycardia and altered blood volume affect atrial dynamics and atrial natriuretic factor release in anesthetized rabbits?
In a rabbit model, systolic right atrial wall stress is a significant factor in atrial natriuretic factor release during tachycardia at high blood volume.
King et al. (1991) studied this question. Tachycardia and blood volume changes was evaluated on right atrial pressure (RAP), right atrial dimension (RAD), and plasma immunoreactive atrial natriuretic factor (IR-ANF). Tachycardia at high blood volume significantly increased plasma immunoreactive atrial natriuretic factor and systolic right atrial wall stress in anesthetized rabbits.
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