Why the study?
Is the modified extraction fluorometric method as accurate as the mass spectrometric method for determining quinidine plasma concentrations in normal human volunteers?
Is the modified extraction fluorometric method as accurate as the mass spectrometric method for determining quinidine plasma concentrations in normal human volunteers?
The extraction fluorometric method is sufficiently accurate for monitoring quinidine plasma concentrations in clinical and research settings compared to mass spectrometry.
Answers are grounded in this paper and cite their sources.
May support fluorometric quinidine monitoring; leaves open validation in larger patient cohorts.
A comparison of two analytical methods of quinidine plasma determination--the modified extraction fluorometric method and the mass spectrometric method--was made. Plasma supplies collected at steady state from normal human volunteers participating in a bioavailability study were analyzed, using both methods. A total of 359 samples were analyzed. Comparison of both sets of values, by linear regression, yielded an r2 value of 0.84. The results of this comparison were consistent with the results reported by others, confirming that the commonly used extraction fluorometric method of quinidine determination is sufficiently accurate for monitoring quinidine plasma concentrations in the patient care setting, as well as for bioavailability comparisons between products.
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Smith et al. (1982) studied this question.
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