Key result
High performance liquid chromatography successfully separated and quantified lidocaine, mexiletine, disopyramide, and quinidine in plasma with coefficients of variation of less than 4%.
Population
Plasma samples
Authors
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May support simultaneous antiarrhythmic monitoring; leaves open clinical validation before routine use.
The study demonstrates a reliable HPLC method for the simultaneous measurement of four common antiarrhythmic drugs in plasma.
Dusci et al. (1985) studied this question. High performance liquid chromatography successfully separated and quantified lidocaine, mexiletine, disopyramide, and quinidine in plasma with coefficients of variation of less than 4%.
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