Key result
Acute pancreatitis can evolve in patients with diabetic ketoacidosis and only mild to moderate hypertriglyceridaemia, challenging the view that triglycerides must be markedly elevated.
Why the study?
The causal factor of acute pancreatitis within the rare triad of acute pancreatitis, hypertriglyceridaemia, and diabetic ketoacidosis remains not fully established.
Case Report (n=1)
No
Acute pancreatitis can occur in patients with diabetic ketoacidosis and only mild to moderate hypertriglyceridaemia, highlighting the need for early management of metabolic disorders.
May prompt pancreatitis evaluation in DKA despite mild hypertriglyceridaemia; hypothesis-generating case report requiring confirmation.
Acute pancreatitis(AP) is one of the common causes of acute abdomen and known to be associated with high morbidity and mortality in severe cases. Though most common causes of AP are cholelithiasis and alcoholism, it has also been reported in association with diabetic ketoacidosis (DKA). Triad of AP, hypertriglyceridaemia (HTG) and DKA is rare co-association and here the causal factor of AP is still not fully established. We report a case of AP in a DKA patient with recent diagnosis of hyperlipidaemia and diabetes. Usually AP has been associated with severe HTG; interestingly, our patient showed only moderate raise in triglycerides but still suffered AP during DKA. Hence, it raises question about the real culprit in this enigmatic triad.
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Thiyagarajan et al. (2019) conducted a case report in Acute pancreatitis, diabetic ketoacidosis, and hypertriglyceridaemia (n=1). Moderate hypertriglyceridaemia during diabetic ketoacidosis was evaluated. Acute pancreatitis can evolve in patients with diabetic ketoacidosis and only mild to moderate hypertriglyceridaemia, challenging the view that triglycerides must be markedly elevated.
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