Key result
Moxonidine pretreatment significantly decreased the incidence of ventricular tachycardia during the first 15 minutes of infarction compared to controls (70% vs 100%) in rats.
Why the study?
Does moxonidine prevent arrhythmias induced by coronary artery occlusion and reperfusion in rats?
Population
Rats subjected to acute myocardial infarction via coronary artery ligation.
Comparison
Moxonidine vs Control animals
Design
Preclinical
Follow-up
15 minutes for infarction model; reperfusion after 6…
Authors
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No immediate clinical implications for arrhythmia prevention; leaves open translation of rat findings to human ischemia-reperfusion.
Does moxonidine prevent arrhythmias induced by coronary artery occlusion and reperfusion in rats?
Absolute Event Rate: 70% vs 100%
Moxonidine pretreatment offers significant protection against arrhythmias induced by acute regional myocardial ischemia and reperfusion in rat models.
Leprán et al. (1994) studied Arrhythmias induced by myocardial ischemia or reperfusion. Moxonidine vs. Control was evaluated on Incidence of ventricular tachycardia during the first 15 min of infarction. Moxonidine pretreatment significantly decreased the incidence of ventricular tachycardia during the first 15 minutes of infarction compared to controls (70% vs 100%) in rats.
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