What does this research mean for the field?

Moxonidine exhibits a dose-dependent antiarrhythmic effect against ouabain-induced cardiac arrhythmias in guinea pigs, likely by reducing sympathetic tone via central imidazoline receptors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1995Annals of the New York Academy of Sciences

Antiarrhythmic Effect of the Selective I₁‐Imidazoline Receptor Modulator Moxonidine on Ouabain‐Induced Cardiac Arrhythmia in Guinea Pigs

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Why the study?

Does moxonidine increase the threshold for ouabain-induced cardiac arrhythmias in guinea pigs?

Population

Guinea pigs

Comparison

Moxonidine (0.1-0.4 mg/kg body weight i.v. in… vs Clonidine, propranolol, or baseline/vehicle

Design

Preclinical

Authors

HMH.‐J. MestEli Lilly (Germany)PTPreben D. ThomsenUniversity of Copenhagen ARAchim RaapLudwig-Maximilians-Universität München

Discussion

Member takes

Implication

Animal data support antiarrhythmic investigation of imidazoline agonism; leaves open translation to human arrhythmias.

Structured PICO

Does moxonidine increase the threshold for ouabain-induced cardiac arrhythmias in guinea pigs?

Population

Guinea pigs (in vivo model of ouabain-induced arrhythmia and in vitro spontaneously beating auricle model of aconitine-induced extrasystoles)

Intervention

Moxonidine (0.1-0.4 mg/kg body weight i.v. in vivo; 10(-7)-10(-8) M in vitro)

Comparator

Clonidine (0.2-0.8 mg/kg body weight i.v.), propranolol, or baseline/vehicle

Outcome

Threshold dose of ouabain needed to induce ventricular arrhythmia (tachycardia, premature ventricular beats, flutter, fibrillation) and asystole; number of aconitine-induced extrasystolessurrogate

Moxonidine demonstrates antiarrhythmic effects against ouabain-induced arrhythmias in guinea pigs, likely mediated by a reduction in sympathetic tone via central imidazoline receptors.

Cite This Study

Mest et al. (1995) studied this question.

synapsesocial.com/papers/6a1c55851567d2fc4d5ff2fb https://doi.org/10.1111/j.1749-6632.1995.tb32457.x

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Antiarrhythmic Effect of the Selective I₁‐Imidazoline Receptor Modulator Moxonidine on Ouabain‐Induced Cardiac Arrhythmia in Guinea Pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antiarrhythmic Effect of the Selective I₁‐Imidazoline Receptor Modulator Moxonidine on Ouabain‐Induced Cardiac Arrhythmia in Guinea Pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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