Key result
Analysis of 104 foot-and-mouth disease virus isolates from the 2010 Japan epidemic revealed >99.56% pairwise sequence identity, indicating a single introduction and gradual genetic substitution.
Population
104 foot-and-mouth disease virus (FMDV) isolates from the 2010 epidemic in Japan
Design
Other
Follow-up
less than three months (epidemic duration)
Authors
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Urges rapid FMD containment to limit mutation; leaves open whether single-introduction patterns apply beyond this epidemic.
Observational (n=104)
The study demonstrates that FMDV genetic substitutions occurred gradually during a short epidemic, highlighting the importance of rapid eradication strategies to prevent extensive viral mutation.
Nishi et al. (2016) conducted an observational in Foot-and-mouth disease virus (FMDV) (n=104). FMDV genome evolution was evaluated on Pairwise identity rates of whole L-fragment sequences. Analysis of 104 foot-and-mouth disease virus isolates from the 2010 Japan epidemic revealed >99.56% pairwise sequence identity, indicating a single introduction and gradual genetic substitution.
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