Key result
Lisinopril added to standard therapy significantly reduced ambulatory blood pressure in post-transplant patients to 121/79 mm Hg at 2 years (P=0.03 vs placebo).
Why the study?
Does lisinopril reduce ambulatory blood pressure in post-transplant patients with mild hypertension?
Population
Post-transplant patients with an abnormality of the 24-h ambulatory blood pressure recording, recruited 2 to…
Comparison
Lisinopril added to standard therapy. vs Placebo added to standard therapy.
Design
RCT, randomized, double-blind
Follow-up
24 months
Authors
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May warrant lisinopril addition for post-transplant BP control; extends RCT evidence to this high-risk group.
RCT
Double-blind
randomized
Does lisinopril reduce ambulatory blood pressure in post-transplant patients with mild hypertension?
p-value: p=0.03
In post-transplant patients with mild hypertension, adding lisinopril to standard therapy significantly reduces ambulatory blood pressure and modestly decreases left ventricular mass.
L. H. Opie (2002) conducted an RCT in mild post-transplant hypertension. Lisinopril vs. Placebo was evaluated on ambulatory blood pressure (ABP) (p=0.03). Lisinopril added to standard therapy significantly reduced ambulatory blood pressure in post-transplant patients to 121/79 mm Hg at 2 years (P=0.03 vs placebo).
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