Key result
Exercise induced a similar threefold increase in plasma ANF concentrations in healthy subjects and diabetic patients with or without cardiac autonomic neuropathy (P<0.001).
Why the study?
Does exercise and posture change alter the release of atrial natriuretic factor in diabetic patients with cardiac autonomic neuropathy compared to healthy subjects and diabetics without CAN?
Population
23 age- and sex-matched subjects
Comparison
Exercise and changes of posture vs Healthy subjects and diabetic patients without CAN
Design
Cross-sectional
Authors
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Supports minor autonomic role in exercise ANF release; leaves open effects on volume regulation in diabetic CAN.
Observational (n=23)
Does exercise and posture change alter the release of atrial natriuretic factor in diabetic patients with cardiac autonomic neuropathy compared to healthy subjects and diabetics without CAN?
Effect estimate: threefold increase
p-value: p=<0.001
Exercise induces a similar increase in plasma ANF in diabetic patients with and without cardiac autonomic neuropathy and healthy subjects, suggesting autonomic activation plays a minor role in ANF release during exercise.
Donckier et al. (1989) conducted an observational in Diabetic cardiac autonomic neuropathy (n=23). Exercise and posture changes vs. Baseline/Rest was evaluated on Plasma ANF concentrations during exercise (threefold increase, p=<0.001). Exercise induced a similar threefold increase in plasma ANF concentrations in healthy subjects and diabetic patients with or without cardiac autonomic neuropathy (P<0.001).
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