Key result
Acute ACE inhibition with enalapril decreased splanchnic vascular resistance at rest and abolished splanchnic vasoconstriction during lower body negative pressure in healthy salt-depleted humans.
Why the study?
Does acute ACE inhibition by enalapril alter splanchnic and central hemodynamics in moderately salt-depleted healthy volunteers during lower body negative pressure?
Population
Moderately salt-depleted healthy volunteers (n=10 for splanchnic hemodynamics, n=9 for central hemodynamics)
Comparison
Acute angiotensin-converting enzyme inhibition… vs Baseline during lower body negative pressure
Design
Other
Follow-up
Acute (15-20 minutes of LBNP)
Authors
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Should not change practice in patients; leaves open autonomic effects of ACE inhibition in salt-depleted states.
Does acute ACE inhibition by enalapril alter splanchnic and central hemodynamics in moderately salt-depleted healthy volunteers during lower body negative pressure?
Acute ACE inhibition abolishes splanchnic vasoconstriction during lower body negative pressure in salt-depleted healthy humans, suggesting interference with autonomic nervous system control of the circulation.
Stadeager et al. (1989) studied Healthy volunteers (n=19). Enalapril vs. Before ACE-I (baseline) was evaluated on Splanchnic and central hemodynamics (vascular resistance, heart rate, plasma norepinephrine). Acute ACE inhibition with enalapril decreased splanchnic vascular resistance at rest and abolished splanchnic vasoconstriction during lower body negative pressure in healthy salt-depleted humans.
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