Risk Factors of Sudden Death From Subarachnoid Hemorrhage
Key result
An increase of 5 cigarettes per day elevated sudden-death SAH risk (HR 1.28; 95% CI 1.17-1.39) more than hospitalized SAH risk (P=0.05 for difference), as did higher systolic blood pressure.
Population
65,521 individuals from the population-based FINRISK study cohort
Design
Cohort
Follow-up
1.52 million person-years
Authors
Discussion
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Implication
Risk factor differences may exist for sudden-death versus hospitalized SAH; hypothesis-generating and requires prospective validation before guiding prevention.
Study Design
Type
Cohort (n=65,521)
Structured PICO
P
Population
65,521 individuals from the population-based FINRISK cohort followed for 1.52 million person-years to evaluate risk factors for sudden-death versus hospitalized subarachnoid hemorrhage.
O
Outcome
Differences in risk factors between hospitalized subarachnoid hemorrhage (SAH) and sudden-death SAHhard clinical
Main Result
Hazard Ratio: 1.28 (95% CI 1.17–1.39)
p-value: p=0.05
Adverse risk factors such as smoking, higher systolic blood pressure, and living without a partner are more strongly associated with sudden-death SAH than with hospitalized SAH.
Cite This Study
Lindbohm et al. (2017) conducted a cohort in Subarachnoid hemorrhage (n=65,521). Smoking (per 5 cigarettes/day increase) vs. Fewer cigarettes/day was evaluated on Sudden-death SAH (HR 1.28, 95% CI 1.17-1.39, p=0.05). An increase of 5 cigarettes per day elevated sudden-death SAH risk (HR 1.28; 95% CI 1.17-1.39) more than hospitalized SAH risk (P=0.05 for difference), as did higher systolic blood pressure.