Key result
Tedisamil infusion in rats caused death via respiratory depression in spontaneously breathing animals and direct cardiac actions in ventilated animals at 2-3 times higher doses.
Population
Ventilated or spontaneously breathing rats subjected to blockade of their peripheral somatic and autonomic…
Design
Preclinical
Authors
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Tedisamil toxicity in rat models signals need for caution in clinical development; leaves open human safety and efficacy questions.
Tedisamil induces acute toxicity primarily through respiratory depression in spontaneously breathing rats and direct cardiac actions in ventilated rats, with arrhythmias potentially mediated by the autonomic system.
Hayes et al. (1993) studied Acute toxicity. Tedisamil was evaluated on Lethal dose and mechanism of death. Tedisamil infusion in rats caused death via respiratory depression in spontaneously breathing animals and direct cardiac actions in ventilated animals at 2-3 times higher doses.
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