Why the study?
Does sotalol alter coronary circulation and heart metabolism in healthy subjects at rest and during work?
Does sotalol alter coronary circulation and heart metabolism in healthy subjects at rest and during work?
Beta-blockade with sotalol blunts the normal exercise-induced increases in cardiac output and coronary blood flow, likely unmasking alpha-adrenergic vasoconstriction.
Answers are grounded in this paper and cite their sources.
May warrant caution with exercise; leaves open effects in patients with cardiovascular disease.
The effect of an adrenergic β‐receptor blocker (sotalol) on coronary circulation and heart metabolism has been studied in six healthy subjects at rest and during work. Sotalol did not produce any uniform effects at rest. During work sotalol reduced the increase of cardiac output, oxygen consumption and coronary blood flow as well as the lowering of the total peripheral resistance which is produced by muscle activity. Despite the fact that sotalol reduced the work of the heart musculature and its oxygen consumption, oxygen extraction from coronary blood was increased. The pyruvate/lactate quotient in coronary venous blood was decreased during work by sotalol. The mechanism for reduction of metabolic vasodilatation by sotalol is discussed. It seems probable that after β‐receptor blockade the contracting effect of adrenergic α‐receptor stimulation gains an increased significance.
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Ekström-Jodal et al. (1972) studied this question.
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