Why the study?
Does FR 76830 improve cardiac mechanical function and metabolism during ischemia and reperfusion in isolated rat hearts compared to diltiazem?
Does FR 76830 improve cardiac mechanical function and metabolism during ischemia and reperfusion in isolated rat hearts compared to diltiazem?
Bradycardia induced by FR 76830 protects myocardial cells during early ischemia and preserves ATP, but decreasing the double product is necessary to improve myocardial pH during late ischemia.
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Reducing double product may be needed for late pH protection; animal data leave open any clinical role for FR 76830.
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Ishibashi et al. (1990) studied this question.
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