Why the study?
Does a high loading dose of clopidogrel improve inhibition of platelet aggregation compared to standard clopidogrel or ticlopidine in patients undergoing coronary stent placement?
Population
30 patients undergoing coronary stent placement
Comparison
Clopidogrel 600 mg loading dose plus 2 x 75 mg… vs Ticlopidine 2 x 500 mg loading dose and 2 x 250…
Design
RCT, randomised into three treatment arms
Follow-up
48 hours
Authors
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A 600 mg clopidogrel loading dose enables faster platelet inhibition in stenting; extends RCT evidence favoring high-dose over standard clopidogrel or ticlopidine.
Does a high loading dose of clopidogrel improve inhibition of platelet aggregation compared to standard clopidogrel or ticlopidine in patients undergoing coronary stent placement?
A 600 mg loading dose of clopidogrel achieves faster and more potent inhibition of platelet aggregation than a 300 mg loading dose or ticlopidine in patients undergoing coronary stenting.
Andrew Thorns (2001) studied this question.