Chronic oral treatment with the AT1 receptor antagonist TCV-116, but not the ACE inhibitor imidapril, abolishes the pressor effect of angiotensin II in the rostral ventrolateral medulla of spontaneously hypertensive rats.
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Differential central effects of AT1 antagonism versus ACE inhibition merit further study; leaves open translation to human hypertension.
Tsuchihashi et al. (1999) studied this question.
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