Why the study?
Do calcium antagonists alter the blood pressure response to alpha-adrenoceptor agonists and antagonists in healthy normotensives?
Population
Healthy normotensive subjects
Comparison
Verapamil 160 mg + prazosin 1 mg orally… vs Placebo
Design
RCT, randomized, placebo-controlled
Authors
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Verapamil potentiates prazosin hypotension; extends evidence that calcium antagonists modify alpha-adrenoceptor responses, supporting combination exploration.
Do calcium antagonists alter the blood pressure response to alpha-adrenoceptor agonists and antagonists in healthy normotensives?
Calcium antagonists can modify responses to both alpha 1- and alpha 2-receptors, suggesting potential additional antihypertensive activity when combined with drugs modifying adrenoceptor activity.
Reid et al. (1985) studied this question.
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