Population
6 hypothyroid patients with extreme elevations (17- to 160-fold) of serum creatine phosphokinase (CPK) levels
Design
Case_series
Authors
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May help differentiate skeletal from cardiac CK sources in hypothyroidism; leaves open validation in larger cohorts.
Extreme elevations of CPK in hypothyroidism are primarily of the MM isoenzyme type, indicating a skeletal muscle source rather than myocardial injury.
Jee Goldman (1977) studied this question.
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