Key result
Prolonged enflurane anesthesia (9.6 MAC hours) caused minimal or no kidney or liver injury in 12 healthy male volunteers, similar to halothane, isoflurane, fluroxene, and diethyl ether.
Why the study?
Does prolonged enflurane anesthesia cause kidney or liver injury in young healthy male volunteers?
Does prolonged enflurane anesthesia cause kidney or liver injury in young healthy male volunteers?
Prolonged enflurane anesthesia without surgical stress appears safe for the kidney and liver in healthy young males.
Answers are grounded in this paper and cite their sources.
Enflurane may spare kidney and liver function in healthy volunteers; leaves open effects during surgery or in patients with comorbidities.
Blood chemistries revealed minimal or no injury to the kidney or liver in 12 young healthy male volunteers subject to 9.6 MAC hours of enflurane anesthesia without surgical stress. The results were similar to those previously obtained with halothane, isoflurane, fluroxene, and diethy ether.
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EGER et al. (1976) studied this question. Prolonged enflurane anesthesia (9.6 MAC hours) caused minimal or no kidney or liver injury in 12 healthy male volunteers, similar to halothane, isoflurane, fluroxene, and diethyl ether.
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